Synthesis of conformationally constrained, orthogonally protected 3-azabicyclo[3.2.1]octane β-amino esters
نویسندگان
چکیده
منابع مشابه
Tin(II) chloride assisted synthesis of N-protected γ-amino β-keto esters through semipinacol rearrangement.
A facile synthetic route for the preparation of N-protected γ-amino β-keto esters from amino aldehydes and ethyl diazoacetate is described. The two component coupling is facilitated by tin(II) chloride followed by semipinacol rearrangement leading to the product in quantitative yield. The reaction is mild, instantaneous and compatible with Boc-, Fmoc- and Cbz-amino protecting groups.
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2010
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0011.904